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Transcriptional regulation

Gene Regulation

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Gene Regulation in Eukaryotes The latest estimates are that a human cell, a eukaryotic cell, contains some 21,000 genes. Some of these are expressed in all cells all the time. These so-called housekeeping genes are responsible for the routine metabolic functions (e.g. respiration) common to all cells. Some are expressed as a cell enters a particular pathway of differentiation. Some are expressed all the time in only those cells that have differentiated in a particular way. For example, a plasma cell expresses continuously the genes for the antibody it synthesizes. Some are expressed only as conditions around and in the cell change. For example, the arrival of a hormone may turn on (or off) certain genes in that cell.

AP Biology Chapter 18 Notes Campbell/Reece

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Chapter 18 Regulation of Gene Expression Conducting the Genetic Orchestra Cells precisely regulate their gene expression. Both prokaryotes and eukaryotes must alter thaier patterns of gene expression in response to changes in the environment. Remember, each cell contains the same genetic information, but the liver cell and brain cell express very different proteins, etc. This chapter will look at how cells (bacteria, eukayotes, etc.) regulate expression of their genes. Point: in eukaryotes, the expression of a gene is often regulated at the level of transcription. Learn this. Point: disruptions in gene regulation can lead to cancer 18.1 Bacteria often respond to environmental change by regulating Transcription
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