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Cancer

Genetic Testing PP

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Single cell fertilized egg 1 cell type, single DNA code Embryo hundreds of cell types, same DNA code Each cell type is defined by the genes that are expressed in that cell ?Gene expression? Single cell fertilized egg 1 cell type, single DNA code Neuron Hemoglobin ? Dopamine + Myoglobin - Muscle cells Hemoglobin ? Dopamine + Myoglobin - Red blood cells Hemoglobin ? Dopamine + Myoglobin - Each cell type only expressed a restricted subset of genes Single cell fertilized egg 1 cell type, single DNA code Neuron Hemoglobin ? Dopamine + Myoglobin - Muscle cells Hemoglobin ? Dopamine + Myoglobin - Red blood cells Hemoglobin ? Dopamine + Myoglobin - Each cell type only expressed a restricted subset of genes How??? Epigenetic marks applied to DNA

Cancer

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BIOLOGY NOTES MONDAY 17, 2014 (CHAPTER 11) 6 Characteristics of cancerous cells Grow when should not Continue to grow when other cells send ?stop? signals When change in their DNA, Apoptosis doesn?t occur Can co-opt vascular system creating new blood vessels Immortal (MOST IMPORTANT) Can metastasis, which moving to other parts Mutations in 2 types of genes cause cancer Positive growth regulators Negative growth regulators Explain how the mutations cause runaway all proliferation More positive growth, results in hyperactivity Uncontrolled cell division, No brakes 2 types of genes Proto-oncogene- Normal Function- Promote cell division (code for positive growth regulator) Mutation- Runaway cell division causing hyperactivity

Cancer

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BIOLOGY NOTES MONDAY 17, 2014 (CHAPTER 11) 6 Characteristics of cancerous cells Grow when should not Continue to grow when other cells send ?stop? signals When change in their DNA, Apoptosis doesn?t occur Can co-opt vascular system creating new blood vessels Immortal (MOST IMPORTANT) Can metastasis, which moving to other parts Mutations in 2 types of genes cause cancer Positive growth regulators Negative growth regulators Explain how the mutations cause runaway all proliferation More positive growth, results in hyperactivity Uncontrolled cell division, No brakes 2 types of genes Proto-oncogene- Normal Function- Promote cell division (code for positive growth regulator) Mutation- Runaway cell division causing hyperactivity
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